# Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload

> **NCT06166654** · PHASE4 · RECRUITING · sponsor: **Johannes Grand** · enrollment: 939 (estimated)

## Conditions studied

- Acute Heart Failure

## Interventions

- **DRUG:** Acetazolamide
- **DRUG:** Metolazone 2.5 MG
- **OTHER:** Double-placebo

## Key facts

- **NCT ID:** NCT06166654
- **Lead sponsor:** Johannes Grand
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-09-05
- **Primary completion:** 2027-09-30
- **Final completion:** 2027-09-30
- **Target enrollment:** 939 (ESTIMATED)
- **Last updated:** 2025-02-20


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06166654

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06166654, "Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT06166654. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*