# Evaluation of Efficacy and Safety of VX-548 for Painful Lumbosacral Radiculopathy (PLSR)

> **NCT06176196** · PHASE2 · COMPLETED · sponsor: **Vertex Pharmaceuticals Incorporated** · enrollment: 218 (actual)

## Conditions studied

- Painful Lumbosacral Radiculopathy

## Interventions

- **DRUG:** VX-548
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT06176196
- **Lead sponsor:** Vertex Pharmaceuticals Incorporated
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2023-12-13
- **Primary completion:** 2024-10-02
- **Final completion:** 2024-10-16
- **Target enrollment:** 218 (ACTUAL)
- **Last updated:** 2025-10-01


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06176196

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06176196, "Evaluation of Efficacy and Safety of VX-548 for Painful Lumbosacral Radiculopathy (PLSR)". Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/clinical/NCT06176196. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*