# Examining Intranasal Oxytocin Augmentation of Brief Couples Therapy for Veterans With PTSD

> **NCT06194851** · PHASE2 · RECRUITING · sponsor: **VA Office of Research and Development** · enrollment: 240 (estimated)

## Conditions studied

- Post-Traumatic Stress Disorder (PTSD)

## Interventions

- **DRUG:** Oxytocin nasal spray
- **DRUG:** Saline nasal spray
- **BEHAVIORAL:** Brief Cognitive-Behavioral Conjoint Therapy

## Key facts

- **NCT ID:** NCT06194851
- **Lead sponsor:** VA Office of Research and Development
- **Sponsor class:** FED
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-10-28
- **Primary completion:** 2028-09-30
- **Final completion:** 2028-09-30
- **Target enrollment:** 240 (ESTIMATED)
- **Last updated:** 2026-05-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06194851

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06194851, "Examining Intranasal Oxytocin Augmentation of Brief Couples Therapy for Veterans With PTSD". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT06194851. Licensed CC0.

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