Tailored Vs. Empirical Helicobacter Pylori Infection Treatment

Conditions

• Helicobacter Pylori Infection

Interventions

• DIAGNOSTIC_TEST: Clarithromycin (mutations in the 23S rRNA gene, A2134G, A2142G and A2142C mutations) and levofloxacin resistance (mutations in the gyrA gene) PCR test
• DRUG: Empirically H. pylori eradication treatment with bismuth quadruple therapy (Pylera®)
• DRUG: PPI, amoxicillin 1 g and clarithromycin 500 mg, twice daily, for 10 days
• DRUG: PPI, amoxicillin 1g and levofloxacin 250 mg, twice daily, for 10 days
• DRUG: Bismuth quadruple therapy (Pylera®) for 10 days

Sponsor

Manuel Coelho da Rocha