# A Study to Assess Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Reduced Ejection Fraction (Cycle-1-REF)

> **NCT06215911** · PHASE2 · COMPLETED · sponsor: **Cardurion Pharmaceuticals, Inc.** · enrollment: 557 (actual)

## Conditions studied

- Heart Failure
- Heart Failure With Reduced Ejection Fraction
- Cardiovascular Diseases
- Heart Diseases

## Interventions

- **DRUG:** Tovinontrine (CRD-750)
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT06215911
- **Lead sponsor:** Cardurion Pharmaceuticals, Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2024-02-13
- **Primary completion:** 2025-10-10
- **Final completion:** 2025-10-10
- **Target enrollment:** 557 (ACTUAL)
- **Last updated:** 2025-11-17


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06215911

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06215911, "A Study to Assess Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Reduced Ejection Fraction (Cycle-1-REF)". Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/clinical/NCT06215911. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*