# Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity Evaluation

> **NCT06221722** · — · RECRUITING · sponsor: **Xijing Hospital of Digestive Diseases** · enrollment: 150 (estimated)

## Conditions studied

- Constipation - Functional
- Refractory Constipation
- Fluoxetine
- fMRI
- Brain Connectivity
- Treatment Efficacy
- Somatic Symptom
- Mental Symptom

## Interventions

- **DIAGNOSTIC_TEST:** BOLD-fMRI
- **DRUG:** Regular treatment of functional constipation
- **DRUG:** fluoxetine

## Key facts

- **NCT ID:** NCT06221722
- **Lead sponsor:** Xijing Hospital of Digestive Diseases
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** RECRUITING
- **Start date:** 2023-11-01
- **Primary completion:** 2025-09-01
- **Final completion:** 2026-09-01
- **Target enrollment:** 150 (ESTIMATED)
- **Last updated:** 2025-07-24


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06221722

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06221722, "Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity Evaluation". Retrieved via AI Analytics 2026-06-03 from https://api.ai-analytics.org/clinical/NCT06221722. Licensed CC0.

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