# Circadian Rhythmicity During Coma Awakening

> **NCT06245434** · NA · RECRUITING · sponsor: **Hospices Civils de Lyon** · enrollment: 90 (estimated)

## Conditions studied

- Acute Brain Injury Coma

## Interventions

- **BEHAVIORAL:** Repeated behavioural assessment
- **BEHAVIORAL:** Act-Pass paradigm
- **BEHAVIORAL:** Biological measures of circadian and monoamines biomarkers
- **BEHAVIORAL:** Transcriptomic and genomic analysis
- **BEHAVIORAL:** Polysomnography with concomitant environment recording
- **BEHAVIORAL:** Actimetry
- **BEHAVIORAL:** Morphological MRI
- **BEHAVIORAL:** Assessment of correlation between patients' behaviour and neurophysiological markers of consciousness.

## Key facts

- **NCT ID:** NCT06245434
- **Lead sponsor:** Hospices Civils de Lyon
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-12-02
- **Primary completion:** 2028-12-02
- **Final completion:** 2028-12-02
- **Target enrollment:** 90 (ESTIMATED)
- **Last updated:** 2026-02-06


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06245434

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06245434, "Circadian Rhythmicity During Coma Awakening". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT06245434. Licensed CC0.

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