# Adaptive Boost Radiotherapy to Primary Lesions and Positive Nodes in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer

> **NCT06246344** · — · SUSPENDED · sponsor: **Shandong Cancer Hospital and Institute** · enrollment: 128 (estimated)

## Conditions studied

- Rectal Cancer

## Interventions

- **RADIATION:** Adaptive Boost Radiotherapy
- **RADIATION:** Long course non-ART radiotherapy
- **DRUG:** Concurrent chemotherapy
- **DRUG:** Consolidation Chemotherapy
- **PROCEDURE:** Total mesorectal excision (TME) surgery

## Key facts

- **NCT ID:** NCT06246344
- **Lead sponsor:** Shandong Cancer Hospital and Institute
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** SUSPENDED
- **Start date:** 2023-12-01
- **Primary completion:** 2025-12-01
- **Final completion:** 2028-12-01
- **Target enrollment:** 128 (ESTIMATED)
- **Why stopped:** The study was terminated early for futility based on the interim analysis. The results indicated a low probability of achieving the primary endpoint.
- **Last updated:** 2026-05-01


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06246344

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06246344, "Adaptive Boost Radiotherapy to Primary Lesions and Positive Nodes in the Neoadjuvant Treatment of Locally Advanced Rectal Cancer". Retrieved via AI Analytics 2026-06-08 from https://api.ai-analytics.org/clinical/NCT06246344. Licensed CC0.

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