# Comparative Effectiveness of Two Initial Combination Therapies in Patients With Recent Onset Diabetes

> **NCT06246799** · PHASE3 · RECRUITING · sponsor: **The University of Texas Health Science Center at San Antonio** · enrollment: 256 (estimated)

## Conditions studied

- Type 2 Diabetes (Adult Onset)

## Interventions

- **DRUG:** Tirzepatide
- **DRUG:** Pioglitazone
- **DRUG:** Sitagliptin
- **DRUG:** Metformin HCI XR

## Key facts

- **NCT ID:** NCT06246799
- **Lead sponsor:** The University of Texas Health Science Center at San Antonio
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-11-07
- **Primary completion:** 2029-04-30
- **Final completion:** 2029-06-30
- **Target enrollment:** 256 (ESTIMATED)
- **Last updated:** 2026-03-10

## Collaborators

- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06246799

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06246799, "Comparative Effectiveness of Two Initial Combination Therapies in Patients With Recent Onset Diabetes". Retrieved via AI Analytics 2026-05-19 from https://api.ai-analytics.org/clinical/NCT06246799. Licensed CC0.

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