# SAMe in Prevention of Oxaliplatin-associated Liver Injury

> **NCT06258525** · PHASE2 · NOT_YET_RECRUITING · sponsor: **Cedars-Sinai Medical Center** · enrollment: 30 (estimated)

## Conditions studied

- Colorectal Cancer
- Liver Metastases
- Liver Metastasis Colon Cancer
- Liver Injury
- Sinusoidal Obstruction Syndrome
- 5-Fluorouracil Toxicity
- Liver Toxicity, Chemically-Induced

## Interventions

- **RADIATION:** Standard of care oxaliplatin-based chemotherapy
- **DIETARY_SUPPLEMENT:** S-adenosylmethionine (SAMe) supplement
- **PROCEDURE:** Surgery

## Key facts

- **NCT ID:** NCT06258525
- **Lead sponsor:** Cedars-Sinai Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-07
- **Primary completion:** 2028-08
- **Final completion:** 2028-08
- **Target enrollment:** 30 (ESTIMATED)
- **Last updated:** 2026-05-06

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06258525

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06258525, "SAMe in Prevention of Oxaliplatin-associated Liver Injury". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT06258525. Licensed CC0.

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