# Effect of Long-term Carvedilol to Prevent Decompensation or Death in Patients With Asymptomatic Child-Pugh A5 to B8 Cirrhosis and Clinically Significant Portal Hypertension: a Multicenter Double-blind Randomized Control Trial

> **NCT06263816** · PHASE3 · NOT_YET_RECRUITING · sponsor: **University Hospital, Tours** · enrollment: 290 (estimated)

## Conditions studied

- Asymptomatic Cirrhosis
- Clinically Significant Portal Hypertension

## Interventions

- **DRUG:** Experimental group: Patients will be treated with carvedilol.
- **OTHER:** Control group: Patients will receive a placebo.

## Key facts

- **NCT ID:** NCT06263816
- **Lead sponsor:** University Hospital, Tours
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2025-06-17
- **Primary completion:** 2027-07-17
- **Final completion:** 2030-07-17
- **Target enrollment:** 290 (ESTIMATED)
- **Last updated:** 2025-06-04

## Collaborators

- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06263816

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06263816, "Effect of Long-term Carvedilol to Prevent Decompensation or Death in Patients With Asymptomatic Child-Pugh A5 to B8 Cirrhosis and Clinically Significant Portal Hypertension: a Multicenter Double-blind Randomized Control Trial". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT06263816. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*