225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome
Conditions
- Acute Lymphoblastic Leukemia
- Acute Myeloid Leukemia
- Myelodysplastic Syndrome
Interventions
- BIOLOGICAL: Actinium Ac 225-DOTA-Daratumumab
- PROCEDURE: Biospecimen Collection
- PROCEDURE: Bone Marrow Aspiration
- PROCEDURE: Bone Marrow Biopsy
- PROCEDURE: Computed Tomography
- BIOLOGICAL: Daratumumab
- PROCEDURE: Echocardiography
- DRUG: Fludarabine
- PROCEDURE: Hematopoietic Cell Transplantation
- BIOLOGICAL: Indium In 111-DOTA-Daratumumab
- DRUG: Melphalan
- PROCEDURE: Multigated Acquisition Scan
- PROCEDURE: Radionuclide Imaging
- PROCEDURE: Single Photon Emission Computed Tomography
- DRUG: Sirolimus
- DRUG: Tacrolimus
- RADIATION: Total Marrow and Lymphoid Irradiation
Sponsor
City of Hope Medical Center
Collaborators