# Low Dose Naltrexone Therapy for Complex Regional Pain Syndrome

> **NCT06306157** · PHASE4 · ENROLLING_BY_INVITATION · sponsor: **Hospital for Special Surgery, New York** · enrollment: 40 (estimated)

## Conditions studied

- Complex Regional Pain Syndrome
- Chronic Pain
- Causalgia
- Complex Regional Pain Syndrome Type I
- Complex Regional Pain Syndrome Type II

## Interventions

- **DRUG:** Low dose naltrexone
- **DRUG:** Placebo sugar capsules

## Key facts

- **NCT ID:** NCT06306157
- **Lead sponsor:** Hospital for Special Surgery, New York
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** ENROLLING_BY_INVITATION
- **Start date:** 2024-01-02
- **Primary completion:** 2026-08
- **Final completion:** 2026-11
- **Target enrollment:** 40 (ESTIMATED)
- **Last updated:** 2025-11-26


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06306157

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06306157, "Low Dose Naltrexone Therapy for Complex Regional Pain Syndrome". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT06306157. Licensed CC0.

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