# Novel Approaches for Improving Vascular Function in Veterans With HFpEF

> **NCT06312748** · PHASE1 · RECRUITING · sponsor: **VA Office of Research and Development** · enrollment: 90 (estimated)

## Conditions studied

- Heart Failure With Preserved Ejection Fraction
- Inflammation

## Interventions

- **DRUG:** L-Citrulline
- **DRUG:** Placebo for L-Citrulline
- **DRUG:** BH4
- **DRUG:** Placebo for BH4
- **DRUG:** Atorvastatin
- **DRUG:** Placebo for Atorvastatin

## Key facts

- **NCT ID:** NCT06312748
- **Lead sponsor:** VA Office of Research and Development
- **Sponsor class:** FED
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2021-05-19
- **Primary completion:** 2028-09-30
- **Final completion:** 2030-09-30
- **Target enrollment:** 90 (ESTIMATED)
- **Last updated:** 2026-04-23

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06312748

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06312748, "Novel Approaches for Improving Vascular Function in Veterans With HFpEF". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT06312748. Licensed CC0.

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