Adaptive De-intensified Radiotherapy Using Circulating Tumor DNA in HPV- Associated Oropharyngeal Cancer

NCT06323460 · clinicaltrials.gov ↗

PHASE2

Phase

RECRUITING

Status

45

Enrollment

OTHER

Sponsor class

Conditions

Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
Oropharyngeal Squamous Cell Carcinoma

Interventions

PROCEDURE: Biospecimen Collection
DRUG: Carboplatin
DRUG: Cisplatin
PROCEDURE: Computed Tomography
RADIATION: External Beam Radiation Therapy
DRUG: Paclitaxel
PROCEDURE: Positron Emission Tomography
OTHER: Questionnaire Administration

Sponsor

Ohio State University Comprehensive Cancer Center