# Impact of Discontinuing Hypertonic Saline in People With CF on Highly Effective CFTR Modulators- A SIMPLIFY Sub-Study

> **NCT06350461** · NA · COMPLETED · sponsor: **Nicole Hamblett** · enrollment: 370 (actual)

## Conditions studied

- Cystic Fibrosis

## Interventions

- **OTHER:** Discontinuation of hypertonic saline (HS)
- **OTHER:** Continuation of hypertonic saline (HS)

## Key facts

- **NCT ID:** NCT06350461
- **Lead sponsor:** Nicole Hamblett
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2020-08-25
- **Primary completion:** 2022-07-11
- **Final completion:** 2022-07-11
- **Target enrollment:** 370 (ACTUAL)
- **Last updated:** 2024-10-01

## Collaborators

- [object Object]
- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06350461

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06350461, "Impact of Discontinuing Hypertonic Saline in People With CF on Highly Effective CFTR Modulators- A SIMPLIFY Sub-Study". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT06350461. Licensed CC0.

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