# PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, Sabestomig, and AZD9592 in HNSCC

> **NCT06366451** · EARLY_PHASE1 · RECRUITING · sponsor: **Presage Biosciences** · enrollment: 15 (estimated)

## Conditions studied

- Head and Neck Squamous Cell Carcinoma

## Interventions

- **BIOLOGICAL:** Rilvegostomig
- **BIOLOGICAL:** Volrustomig
- **BIOLOGICAL:** Sabestomig
- **BIOLOGICAL:** AZD9592
- **BIOLOGICAL:** Pembrolizumab
- **COMBINATION_PRODUCT:** AZD9592 + Rilvegostomig
- **COMBINATION_PRODUCT:** AZD9592 + Volrustomig
- **COMBINATION_PRODUCT:** AZD9592 + Sabestomig
- **COMBINATION_PRODUCT:** AZD9592 + Pembrolizumab

## Key facts

- **NCT ID:** NCT06366451
- **Lead sponsor:** Presage Biosciences
- **Sponsor class:** INDUSTRY
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-05-22
- **Primary completion:** 2025-02
- **Final completion:** 2025-04
- **Target enrollment:** 15 (ESTIMATED)
- **Last updated:** 2025-01-20

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06366451

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06366451, "PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, Sabestomig, and AZD9592 in HNSCC". Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/clinical/NCT06366451. Licensed CC0.

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