# Evaluating the Human Immune Response to the JYNNEOS Vaccine

> **NCT06366672** · EARLY_PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **Washington University School of Medicine** · enrollment: 20 (estimated)

## Conditions studied

- Vaccinia
- Virus Diseases

## Interventions

- **BIOLOGICAL:** JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) suspension for subcutaneous injection
- **PROCEDURE:** Phlebotomy
- **PROCEDURE:** Research bronchoscopy
- **PROCEDURE:** Skin punch biopsy
- **PROCEDURE:** Bone marrow aspiration

## Key facts

- **NCT ID:** NCT06366672
- **Lead sponsor:** Washington University School of Medicine
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2024-06-10
- **Primary completion:** 2026-09
- **Final completion:** 2026-12
- **Target enrollment:** 20 (ESTIMATED)
- **Last updated:** 2025-10-16


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06366672

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06366672, "Evaluating the Human Immune Response to the JYNNEOS Vaccine". Retrieved via AI Analytics 2026-06-04 from https://api.ai-analytics.org/clinical/NCT06366672. Licensed CC0.

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