# A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

> **NCT06368817** · PHASE2 · RECRUITING · sponsor: **Children's Oncology Group** · enrollment: 240 (estimated)

## Conditions studied

- Basal Ganglia Germinoma
- Diabetes Insipidus
- Germinoma
- Pineal Region Germinoma
- Suprasellar Germinoma
- Thalamic Germinoma

## Interventions

- **RADIATION:** 3-Dimensional Conformal Proton Radiation Therapy
- **RADIATION:** 3-Dimensional Conformal Radiation Therapy
- **PROCEDURE:** Biospecimen Collection
- **DRUG:** Carboplatin
- **DRUG:** Etoposide
- **PROCEDURE:** Intensity-Modulated Proton Therapy
- **RADIATION:** Intensity-Modulated Radiation Therapy
- **PROCEDURE:** Lumbar Puncture
- **PROCEDURE:** Magnetic Resonance Imaging
- **OTHER:** Questionnaire Administration
- **PROCEDURE:** Surgical Procedure

## Key facts

- **NCT ID:** NCT06368817
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-10-22
- **Primary completion:** 2033-11-04
- **Final completion:** 2033-11-04
- **Target enrollment:** 240 (ESTIMATED)
- **Last updated:** 2026-05-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06368817

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06368817, "A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT06368817. Licensed CC0.

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