# A Prospective Single Arm Phase II Exploratory Study on the Combination of Whole Brain Radiotherapy, Thiotepa Intrathecal Injection and Systemic Treatment of Primary Diseases in the Treatment of Solid Tumor Leptomeningeal Metastasis

> **NCT06376292** · PHASE2 · COMPLETED · sponsor: **Second Affiliated Hospital, School of Medicine, Zhejiang University** · enrollment: 58 (actual)

## Conditions studied

- Solid Tumor Leptomeningeal Metastasis

## Interventions

- **DRUG:** Intrathecal Injection of Thiotepa+Radiation+Systemic Treatment of Primary Diseases

## Key facts

- **NCT ID:** NCT06376292
- **Lead sponsor:** Second Affiliated Hospital, School of Medicine, Zhejiang University
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2024-01-06
- **Primary completion:** 2025-09-01
- **Final completion:** 2025-09-01
- **Target enrollment:** 58 (ACTUAL)
- **Last updated:** 2026-05-18


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06376292

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06376292, "A Prospective Single Arm Phase II Exploratory Study on the Combination of Whole Brain Radiotherapy, Thiotepa Intrathecal Injection and Systemic Treatment of Primary Diseases in the Treatment of Solid Tumor Leptomeningeal Metastasis". Retrieved via AI Analytics 2026-07-20 from https://api.ai-analytics.org/clinical/NCT06376292. Licensed CC0.

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