Evaluation of Safety and Pharmacokinetics of Oral Controlled-ileal-release Nicotinic Acid (CIR-NA) Compared to Immediate-release Nicotinic Acid and Placebo in Healthy Subjects and Subjects With Prediabetes

Conditions

• Safety Issues
• Pharmacokinetic

Interventions

• DRUG: controlled-ileal-release nicotinic acid (SAD/ MAD/MD) single- and multiple-ascending dose (SAD/MAD) or multiple dose (MD)
• DRUG: immediate-release nicotinic acid (SAD)
• DRUG: Placebo controlled-ileal-release nicotinic acid (SAD/MAD)
• DRUG: Placebo immediate-release nicotinic acid (SAD)

Sponsor

University Hospital Schleswig-Holstein