# Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE Trial

> **NCT06378866** · PHASE2 · RECRUITING · sponsor: **Mayo Clinic** · enrollment: 532 (estimated)

## Conditions studied

- Recurrent Castration-Sensitive Prostate Carcinoma
- Recurrent Prostate Cancer
- Castration-resistant Prostate Cancer
- Biochemically Recurrent Prostate Carcinoma

## Interventions

- **DRUG:** Abiraterone
- **DRUG:** Apalutamide
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Bone Scan
- **PROCEDURE:** Computed Tomography
- **DRUG:** Darolutamide
- **DRUG:** Degarelix
- **DRUG:** Enzalutamide
- **DRUG:** Goserelin
- **DRUG:** Histrelin
- **DRUG:** Leuprolide
- **PROCEDURE:** Magnetic Resonance Imaging
- **OTHER:** Patient Observation
- **PROCEDURE:** Positron Emission Tomography
- **DRUG:** Prednisone
- **OTHER:** Questionnaire Administration
- **DRUG:** Relugolix
- **RADIATION:** Stereotactic Body Radiation Therapy
- **DRUG:** Triptorelin
- **RADIATION:** Radiation Therapy

## Key facts

- **NCT ID:** NCT06378866
- **Lead sponsor:** Mayo Clinic
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-06-03
- **Primary completion:** 2031-02-28
- **Final completion:** 2031-02-28
- **Target enrollment:** 532 (ESTIMATED)
- **Last updated:** 2026-04-20

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06378866

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06378866, "Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE Trial". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT06378866. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*