Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advanced or Metastatic Pancreatic Cancer

NCT06381154 · clinicaltrials.gov ↗

PHASE2

Phase

RECRUITING

Status

25

Enrollment

OTHER

Sponsor class

Conditions

Locally Advanced Pancreatic Adenocarcinoma
Metastatic Pancreatic Adenocarcinoma
Stage II Pancreatic Cancer AJCC v8
Stage III Pancreatic Cancer AJCC v8
Stage IV Pancreatic Cancer AJCC v8
Unresectable Pancreatic Adenocarcinoma

Interventions

PROCEDURE: Biopsy
PROCEDURE: Biospecimen Collection
PROCEDURE: Computed Tomography
PROCEDURE: Endoscopic Ultrasound
DRUG: Fluorouracil
DRUG: Irinotecan
DRUG: Leucovorin
PROCEDURE: Lymph Node Biopsy
PROCEDURE: Magnetic Resonance Imaging
DRUG: Oxaliplatin
BIOLOGICAL: Pembrolizumab
DRUG: Photodynamic Therapy
PROCEDURE: Positron Emission Tomography
OTHER: Questionnaire Administration
DRUG: Verteporfin

Sponsor

Mayo Clinic

Collaborators

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