# Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial

> **NCT06381661** · PHASE2 · NOT_YET_RECRUITING · sponsor: **Assistance Publique - Hôpitaux de Paris** · enrollment: 2000 (estimated)

## Conditions studied

- Sepsis

## Interventions

- **DRUG:** Tocilizumab
- **DRUG:** Baricitinib
- **DRUG:** Anakinra
- **DRUG:** Hydrocortisone
- **DRUG:** Hydrocortisone and fludrocortisone
- **DRUG:** Heparin
- **DRUG:** Low molecular weight heparin
- **DRUG:** Recombinant humanThrombomodulin( rhTM)
- **DRUG:** Sivelestat
- **OTHER:** Usual care
- **OTHER:** blood purification with MTx.100 Plasma Adsorption Column
- **DRUG:** G-CSF filgrastim
- **DRUG:** Interferon gamma-1b
- **DRUG:** Fludrocortisone
- **DRUG:** Prophylactic unfractionated heparin (UFH)
- **DRUG:** Octaplas LG
- **DRUG:** Plasminogen

## Key facts

- **NCT ID:** NCT06381661
- **Lead sponsor:** Assistance Publique - Hôpitaux de Paris
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2026-05-01
- **Primary completion:** 2028-06-01
- **Final completion:** 2031-05-01
- **Target enrollment:** 2000 (ESTIMATED)
- **Last updated:** 2026-01-27


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06381661

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06381661, "Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT06381661. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*