Niraparib, Abiraterone Acetate and Prednisone for mHSPC With Deleterious Homologous Recombination Repair Alterations

Stopped Funder withdrew funding.

Conditions

• Metastatic Hormone-sensitive Prostate Cancer (mHSPC)
• Deleterious HRR Gene Mutation
• BRCA1 Gene Mutation
• BRCA2 Gene Mutation
• BRIP1 Gene Mutation
• CHEK2 Gene Mutation
• FANCA Gene Mutation
• PALB2 Gene Mutation
• RAD51B Gene Mutation
• RAD54L Gene Mutation

Interventions

• DRUG: Androgen Deprivation Therapy (ADT)
• DRUG: Niraparib/Abiraterone Acetate DAT
• DRUG: Abiraterone Acetate
• DRUG: Prednisone
• DRUG: Docetaxel

Sponsor

Qian Qin

Collaborators

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