# Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)

> **NCT06396078** · PHASE4 · RECRUITING · sponsor: **Ohio State University** · enrollment: 56 (estimated)

## Conditions studied

- Preterm Premature Rupture of Membrane
- Pregnancy, High Risk
- Preterm Birth

## Interventions

- **DRUG:** Ceftriaxone 1000 MG
- **DRUG:** Clarithromycin 500mg
- **DRUG:** Metronidazole 500 mg
- **DRUG:** Ampicillin 2 GM Injection
- **DRUG:** Amoxicillin 250 MG
- **DRUG:** Azithromycin
- **DRUG:** Erythromycin

## Key facts

- **NCT ID:** NCT06396078
- **Lead sponsor:** Ohio State University
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-07-18
- **Primary completion:** 2026-12
- **Final completion:** 2026-12
- **Target enrollment:** 56 (ESTIMATED)
- **Last updated:** 2026-01-27


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06396078

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06396078, "Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT06396078. Licensed CC0.

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