# Dual Therapy With Vonoprazan Plus Amoxicillin or Doxycycline Versus Bismuth Quadruple Therapy for Helicobacter Pylori Eradication.

> **NCT06412588** · NA · COMPLETED · sponsor: **Nanjing First Hospital, Nanjing Medical University** · enrollment: 579 (actual)

## Conditions studied

- Helicobacter Pylori Infection

## Interventions

- **DRUG:** Vonoprazan+amoxicillin+doxycycline+bismuth for 14 days
- **DRUG:** Vonoprazan+Amoxicillin
- **DRUG:** Vonoprazan+doxycycline

## Key facts

- **NCT ID:** NCT06412588
- **Lead sponsor:** Nanjing First Hospital, Nanjing Medical University
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2024-06-15
- **Primary completion:** 2026-01-01
- **Final completion:** 2026-01-10
- **Target enrollment:** 579 (ACTUAL)
- **Last updated:** 2026-03-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06412588

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06412588, "Dual Therapy With Vonoprazan Plus Amoxicillin or Doxycycline Versus Bismuth Quadruple Therapy for Helicobacter Pylori Eradication.". Retrieved via AI Analytics 2026-07-09 from https://api.ai-analytics.org/clinical/NCT06412588. Licensed CC0.

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