# Ketamine for Sedation in Severe Traumatic Brain Injury

> **NCT06429657** · PHASE4 · SUSPENDED · sponsor: **Henry M. Jackson Foundation for the Advancement of Military Medicine** · enrollment: 50 (estimated)

## Conditions studied

- Severe Traumatic Brain Injury
- Intracranial Hypertension
- Intracranial Hemorrhage, Hypertensive

## Interventions

- **DRUG:** Ketamine with propofol
- **OTHER:** Standard of Care propofol, fentanyl, dexmedetomidine, morphine, hydromorphone, midazolam, or lorazepam

## Key facts

- **NCT ID:** NCT06429657
- **Lead sponsor:** Henry M. Jackson Foundation for the Advancement of Military Medicine
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** SUSPENDED
- **Start date:** 2024-09-23
- **Primary completion:** 2027-01-01
- **Final completion:** 2027-06-30
- **Target enrollment:** 50 (ESTIMATED)
- **Why stopped:** administrative hold at current open site and awaiting site startup at additional participating sites
- **Last updated:** 2025-07-14

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06429657

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06429657, "Ketamine for Sedation in Severe Traumatic Brain Injury". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT06429657. Licensed CC0.

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