# Behavioural Activation Therapy and Esketamine for Resistant Depression

> **NCT06431386** · NA · TERMINATED · sponsor: **The Royal's Institute of Mental Health Research** · enrollment: 6 (actual)

## Conditions studied

- Depressive Disorder, Treatment-Resistant
- Depressive Disorder, Major
- Bipolar Disorder

## Interventions

- **BEHAVIORAL:** Behavioural Activation (BA) Therapy
- **DRUG:** Esketamine

## Key facts

- **NCT ID:** NCT06431386
- **Lead sponsor:** The Royal's Institute of Mental Health Research
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2024-06-11
- **Primary completion:** 2025-09-17
- **Final completion:** 2025-09-17
- **Target enrollment:** 6 (ACTUAL)
- **Why stopped:** The study was terminated prematurely due to significant recruitment challenges.
- **Last updated:** 2025-10-01


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06431386

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06431386, "Behavioural Activation Therapy and Esketamine for Resistant Depression". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT06431386. Licensed CC0.

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