# A Phase II Study of Neoadjuvant Immunotherapy in Combination With Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma

> **NCT06444009** · PHASE2 · RECRUITING · sponsor: **Lei Liu** · enrollment: 90 (estimated)

## Conditions studied

- Head and Neck Squamous Cell Carcinoma

## Interventions

- **DRUG:** Ivonescimab combined with TP
- **DRUG:** Cadonilimab combined with TP
- **DRUG:** Penpulimab combined with TP

## Key facts

- **NCT ID:** NCT06444009
- **Lead sponsor:** Lei Liu
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-07-01
- **Primary completion:** 2025-12-01
- **Final completion:** 2027-12-01
- **Target enrollment:** 90 (ESTIMATED)
- **Last updated:** 2024-12-02


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06444009

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06444009, "A Phase II Study of Neoadjuvant Immunotherapy in Combination With Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT06444009. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*