# The Nordic Aortic Valve Intervention Trial 4 (NOTION-4)

> **NCT06449469** · NA · ACTIVE_NOT_RECRUITING · sponsor: **Rigshospitalet, Denmark** · enrollment: 352 (actual)

## Conditions studied

- Aortic Valve Stenosis
- Cardiovascular Diseases
- Heart Diseases
- Heart Valve Diseases
- Valve Disease, Aortic

## Interventions

- **DRUG:** Rivaroxaban
- **DRUG:** Acetylsalicylic acid
- **DRUG:** Clopidogrel
- **DRUG:** Edoxaban
- **DRUG:** Dabigatran
- **DRUG:** Apixaban
- **DRUG:** Warfarin

## Key facts

- **NCT ID:** NCT06449469
- **Lead sponsor:** Rigshospitalet, Denmark
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2021-05-01
- **Primary completion:** 2026-04-01
- **Final completion:** 2030-04-01
- **Target enrollment:** 352 (ACTUAL)
- **Last updated:** 2025-04-06

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06449469

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06449469, "The Nordic Aortic Valve Intervention Trial 4 (NOTION-4)". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT06449469. Licensed CC0.

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