# Postoperative Re-irradiaTion With and Without HYPERthermia: Toxicity, Quality of Life and Survival in Patients With Locoregional Recurrent Breast Cancer

> **NCT06452485** · — · RECRUITING · sponsor: **Amsterdam UMC, location VUmc** · enrollment: 500 (estimated)

## Conditions studied

- Locoregional Recurrence
- Breast Cancer
- Re-irradiation
- Hyperthermia

## Interventions

- **OTHER:** No interventions, patient-reported outcomes (PROMs) and toxicity will be collected in both groups.

## Key facts

- **NCT ID:** NCT06452485
- **Lead sponsor:** Amsterdam UMC, location VUmc
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** RECRUITING
- **Start date:** 2024-01-01
- **Primary completion:** 2027-01
- **Final completion:** 2027-05
- **Target enrollment:** 500 (ESTIMATED)
- **Last updated:** 2025-10-06

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06452485

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06452485, "Postoperative Re-irradiaTion With and Without HYPERthermia: Toxicity, Quality of Life and Survival in Patients With Locoregional Recurrent Breast Cancer". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT06452485. Licensed CC0.

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