# Roflumilast and TMS Motor Plasticity

> **NCT06457191** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **University of Calgary** · enrollment: 20 (actual)

## Conditions studied

- Other Conditions of Brain

## Interventions

- **DRUG:** Roflumilast
- **DRUG:** Placebo
- **DEVICE:** Intermittent theta-burst stimulation transcranial magnetic stimulation
- **DEVICE:** Continuous theta-burst stimulation transcranial magnetic stimulation

## Key facts

- **NCT ID:** NCT06457191
- **Lead sponsor:** University of Calgary
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2024-11-06
- **Primary completion:** 2025-08
- **Final completion:** 2026-06
- **Target enrollment:** 20 (ACTUAL)
- **Last updated:** 2025-07-03


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06457191

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06457191, "Roflumilast and TMS Motor Plasticity". Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/clinical/NCT06457191. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*