# Natural History of Depression, Bipolar Disorder and Suicide Risk

> **NCT06462196** · — · RECRUITING · sponsor: **National Institute of Mental Health (NIMH)** · enrollment: 500 (estimated)

## Conditions studied

- Behavioral Symptoms
- Suicide
- Self-Injurious Behavior
- Sensory System Agents
- Analgesics
- Peripheral Nervous System Agents
- Physiological Effects of Drugs
- Anesthetics, Dissociative
- Anesthetics, General
- Anesthetics
- Central Nervous System Depressants
- Excitatory Amino Acid Antagonists
- Excitatory Amino Acid Agents
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Ketamine
- Depression, Unipolar
- Depressive Symptoms
- Treatment Resistant Depression
- Major Depressive Disorder
- Depression, Bipolar

## Interventions

_None listed._

## Key facts

- **NCT ID:** NCT06462196
- **Lead sponsor:** National Institute of Mental Health (NIMH)
- **Sponsor class:** NIH
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** RECRUITING
- **Start date:** 2024-09-09
- **Primary completion:** 2030-06-01
- **Final completion:** 2030-06-01
- **Target enrollment:** 500 (ESTIMATED)
- **Last updated:** 2026-04-29


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06462196

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06462196, "Natural History of Depression, Bipolar Disorder and Suicide Risk". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT06462196. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*