# MUC1-Activated T Cells for the Treatment of Relapsed and Resistant Ovarian Cancer

> **NCT06483048** · PHASE1 · RECRUITING · sponsor: **Mayo Clinic** · enrollment: 12 (estimated)

## Conditions studied

- Platinum-Resistant Fallopian Tube Carcinoma
- Platinum-Resistant Ovarian Carcinoma
- Platinum-Resistant Primary Peritoneal Carcinoma
- Recurrent Fallopian Tube Carcinoma
- Recurrent Fallopian Tube Carcinosarcoma
- Recurrent Female Reproductive System Carcinoma
- Recurrent Ovarian Carcinoma
- Recurrent Ovarian Carcinosarcoma
- Recurrent Platinum-Resistant Fallopian Tube Carcinoma
- Recurrent Platinum-Resistant Ovarian Carcinoma
- Recurrent Primary Peritoneal Carcinoma
- Recurrent Primary Peritoneal Carcinosarcoma
- Refractory Fallopian Tube Carcinoma
- Refractory Female Reproductive System Carcinoma
- Refractory Ovarian Carcinoma
- Refractory Primary Peritoneal Carcinoma

## Interventions

- **BIOLOGICAL:** Autologous MUC1-activated T-cells
- **DRUG:** Bendamustine
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Computed Tomography
- **DRUG:** Cyclophosphamide
- **PROCEDURE:** Echocardiography
- **PROCEDURE:** Leukapheresis
- **PROCEDURE:** Magnetic Resonance Imaging
- **PROCEDURE:** Multigated Acquisition Scan
- **PROCEDURE:** Positron Emission Tomography

## Key facts

- **NCT ID:** NCT06483048
- **Lead sponsor:** Mayo Clinic
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-09-20
- **Primary completion:** 2028-09-30
- **Final completion:** 2028-09-30
- **Target enrollment:** 12 (ESTIMATED)
- **Last updated:** 2026-03-16


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06483048

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06483048, "MUC1-Activated T Cells for the Treatment of Relapsed and Resistant Ovarian Cancer". Retrieved via AI Analytics 2026-07-05 from https://api.ai-analytics.org/clinical/NCT06483048. Licensed CC0.

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