# Clinical Efficacy of Prophylactic Intravenous Neostigmine and Atropine in Preventing Post-Dural Puncture Headache Among Parturient Undergoing Spinal Anesthesia for Cesarean Section: A Double-blind Randomized Placebo-controlled Trial

> **NCT06493838** · PHASE4 · NOT_YET_RECRUITING · sponsor: **Minia University** · enrollment: 180 (estimated)

## Conditions studied

- Acute Pain

## Interventions

- **DRUG:** intravenous 50 mL of saline injection of 0.9% after umbilical cord clamping.
- **DRUG:** Neostigmine 20μg/kg (Neostigmine Methylsulphate 0.5 mg, Amriya Pharm.Ind.) and atropine 0.01 mg/kg (diluted in 50 ml saline; 0.9% for 10 min) following umbilical cord clamping.

## Key facts

- **NCT ID:** NCT06493838
- **Lead sponsor:** Minia University
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2024-07-15
- **Primary completion:** 2025-01-15
- **Final completion:** 2025-01-16
- **Target enrollment:** 180 (ESTIMATED)
- **Last updated:** 2024-07-16


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06493838

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06493838, "Clinical Efficacy of Prophylactic Intravenous Neostigmine and Atropine in Preventing Post-Dural Puncture Headache Among Parturient Undergoing Spinal Anesthesia for Cesarean Section: A Double-blind Randomized Placebo-controlled Trial". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT06493838. Licensed CC0.

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