# Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)

> **NCT06494111** · PHASE2 · RECRUITING · sponsor: **M.D. Anderson Cancer Center** · enrollment: 295 (estimated)

## Conditions studied

- Lymphedema
- Fibrosis

## Interventions

- **DRUG:** Pravastatin
- **DRUG:** Pentoxifylline
- **DRUG:** Tocopherol

## Key facts

- **NCT ID:** NCT06494111
- **Lead sponsor:** M.D. Anderson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-02-13
- **Primary completion:** 2029-05-01
- **Final completion:** 2031-03-01
- **Target enrollment:** 295 (ESTIMATED)
- **Last updated:** 2026-02-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06494111

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06494111, "Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)". Retrieved via AI Analytics 2026-07-02 from https://api.ai-analytics.org/clinical/NCT06494111. Licensed CC0.

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