# Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

> **NCT06500455** · PHASE3 · RECRUITING · sponsor: **NRG Oncology** · enrollment: 269 (estimated)

## Conditions studied

- Anatomic Stage IV Breast Cancer AJCC v8
- Metastatic Breast Carcinoma
- Metastatic Digestive System Carcinoma
- Metastatic Lung Non-Small Cell Carcinoma
- Metastatic Malignant Neoplasm in the Brain
- Metastatic Malignant Solid Neoplasm
- Metastatic Melanoma
- Metastatic Renal Cell Carcinoma
- Stage IV Lung Cancer AJCC v8
- Stage IV Renal Cell Cancer AJCC v8

## Interventions

- **PROCEDURE:** Computed Tomography
- **RADIATION:** Fractionated Stereotactic Radiation Therapy
- **PROCEDURE:** Magnetic Resonance Imaging
- **RADIATION:** Stereotactic Radiosurgery

## Key facts

- **NCT ID:** NCT06500455
- **Lead sponsor:** NRG Oncology
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-12-12
- **Primary completion:** 2028-06-30
- **Final completion:** 2028-06-30
- **Target enrollment:** 269 (ESTIMATED)
- **Last updated:** 2026-05-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06500455

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06500455, "Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT06500455. Licensed CC0.

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