# A Platform Trial for Gram Negative Bloodstream Infections

> **NCT06537609** · NA · RECRUITING · sponsor: **Sunnybrook Health Sciences Centre** · enrollment: 2500 (estimated)

## Conditions studied

- Gram-negative Bacteremia

## Interventions

- **OTHER:** De-escalation VS No De-escalation
- **OTHER:** Oral beta-lactams VS non beta-lactams
- **OTHER:** Central vascular catheter retention VS Central vascular catheter replacement
- **OTHER:** Cephalosporin VS Carbapenem for low risk AmpC organisms
- **OTHER:** Routine follow-up blood culture VS No routine follow-up blood culture

## Key facts

- **NCT ID:** NCT06537609
- **Lead sponsor:** Sunnybrook Health Sciences Centre
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-04-24
- **Primary completion:** 2027-04
- **Final completion:** 2028-04
- **Target enrollment:** 2500 (ESTIMATED)
- **Last updated:** 2026-02-10

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06537609

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06537609, "A Platform Trial for Gram Negative Bloodstream Infections". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT06537609. Licensed CC0.

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