# Mannitol-induced Release of Copeptin in Healthy Adults and Patients With Polyuria-Polydipsia Syndrome (MARS Study)

> **NCT06542198** · NA · COMPLETED · sponsor: **University Hospital, Basel, Switzerland** · enrollment: 42 (actual)

## Conditions studied

- Polyuria-polydipsia Syndrome
- Arginine Vasopressin Deficiency
- Primary Polydipsia

## Interventions

- **DIAGNOSTIC_TEST:** Mannitol Infusion (blinded)
- **DIAGNOSTIC_TEST:** Placebo Infusion (blinded)
- **DIAGNOSTIC_TEST:** Mannitol Infusion (open label)

## Key facts

- **NCT ID:** NCT06542198
- **Lead sponsor:** University Hospital, Basel, Switzerland
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2024-09-10
- **Primary completion:** 2025-07-22
- **Final completion:** 2025-07-22
- **Target enrollment:** 42 (ACTUAL)
- **Last updated:** 2025-12-15


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06542198

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06542198, "Mannitol-induced Release of Copeptin in Healthy Adults and Patients With Polyuria-Polydipsia Syndrome (MARS Study)". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT06542198. Licensed CC0.

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