# Testing the Addition of an Investigational Anti-Cancer Drug, ASTX660 (Tolinapant), to a Usual Chemotherapy Treatment (Eribulin) for Treatment of Advanced Triple Negative Breast Cancer

> **NCT06590558** · PHASE1 · WITHDRAWN · sponsor: **National Cancer Institute (NCI)**

## Conditions studied

- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage IV Breast Cancer AJCC v8
- Invasive Breast Carcinoma
- Locally Advanced HER2-Negative Breast Carcinoma
- Locally Advanced Hormone Receptor-Positive Breast Carcinoma
- Locally Advanced Triple-Negative Breast Carcinoma
- Metastatic HER2-Negative Breast Carcinoma
- Metastatic Hormone Receptor-Positive Breast Carcinoma
- Metastatic Triple-Negative Breast Carcinoma
- Unresectable HER2-Negative Breast Carcinoma
- Unresectable Hormone Receptor-Positive Breast Carcinoma
- Unresectable Triple-Negative Breast Carcinoma

## Interventions

- **PROCEDURE:** Biopsy Procedure
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Computed Tomography
- **DRUG:** Eribulin Mesylate
- **PROCEDURE:** Magnetic Resonance Imaging
- **DRUG:** Tolinapant
- **PROCEDURE:** X-Ray Imaging

## Key facts

- **NCT ID:** NCT06590558
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** WITHDRAWN
- **Start date:** 2025-08-04
- **Primary completion:** 2027-05-17
- **Final completion:** 2027-05-17
- **Target enrollment:** 0 (ACTUAL)
- **Why stopped:** Manually added per CS0177524- Weekly CTEP status report.
- **Last updated:** 2025-07-03


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06590558

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06590558, "Testing the Addition of an Investigational Anti-Cancer Drug, ASTX660 (Tolinapant), to a Usual Chemotherapy Treatment (Eribulin) for Treatment of Advanced Triple Negative Breast Cancer". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT06590558. Licensed CC0.

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