# A Randomized Controlled Trial Comparing the Effectiveness of Different Treatment Options for Weight Management After Discontinuation of Semaglutide and Tirzepatide (GLP1 Transition Trial)

> **NCT06605703** · PHASE4 · COMPLETED · sponsor: **WW International Inc** · enrollment: 226 (actual)

## Conditions studied

- Obesity
- Overweight

## Interventions

- **BEHAVIORAL:** WW Clinic
- **DRUG:** Bupropion-Naltrexone
- **DRUG:** Bupropion-Naltrexone-Metformin

## Key facts

- **NCT ID:** NCT06605703
- **Lead sponsor:** WW International Inc
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2024-09-18
- **Primary completion:** 2026-02-05
- **Final completion:** 2026-02-05
- **Target enrollment:** 226 (ACTUAL)
- **Last updated:** 2026-04-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06605703

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06605703, "A Randomized Controlled Trial Comparing the Effectiveness of Different Treatment Options for Weight Management After Discontinuation of Semaglutide and Tirzepatide (GLP1 Transition Trial)". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT06605703. Licensed CC0.

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