# Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression

> **NCT06610305** · PHASE4 · RECRUITING · sponsor: **University of North Carolina, Chapel Hill** · enrollment: 75 (estimated)

## Conditions studied

- Major Depressive Disorder

## Interventions

- **DRUG:** Transdermal estradiol
- **DRUG:** Progesterone
- **DRUG:** Transdermal placebo patch
- **DRUG:** placebo capsule

## Key facts

- **NCT ID:** NCT06610305
- **Lead sponsor:** University of North Carolina, Chapel Hill
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-09-02
- **Primary completion:** 2028-06-01
- **Final completion:** 2028-06-01
- **Target enrollment:** 75 (ESTIMATED)
- **Last updated:** 2025-10-29

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06610305

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06610305, "Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression". Retrieved via AI Analytics 2026-06-30 from https://api.ai-analytics.org/clinical/NCT06610305. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*