# Does a Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Nat hx With Its Numerous Co-morbidities?

> **NCT06616363** · — · RECRUITING · sponsor: **Virginia Commonwealth University** · enrollment: 120 (estimated)

## Conditions studied

- POTS - Postural Orthostatic Tachycardia Syndrome

## Interventions

- **BEHAVIORAL:** Questionnaires to be competed
- **BEHAVIORAL:** Provide list of medication and lifetime events
- **BEHAVIORAL:** Use phone App to record new life events
- **DEVICE:** Will wear an activity monitor
- **OTHER:** Periodic 24-hour urine sodium check
- **DIAGNOSTIC_TEST:** A fMRI scan
- **DIAGNOSTIC_TEST:** A bedside tilt test will be performed
- **OTHER:** IV placed to collect blood samples
- **OTHER:** Stool Sample

## Key facts

- **NCT ID:** NCT06616363
- **Lead sponsor:** Virginia Commonwealth University
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** RECRUITING
- **Start date:** 2024-05-29
- **Primary completion:** 2028-07
- **Final completion:** 2028-07
- **Target enrollment:** 120 (ESTIMATED)
- **Last updated:** 2025-09-26

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06616363

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06616363, "Does a Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Nat hx With Its Numerous Co-morbidities?". Retrieved via AI Analytics 2026-07-26 from https://api.ai-analytics.org/clinical/NCT06616363. Licensed CC0.

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