# A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer

> **NCT06630325** · PHASE2 · TERMINATED · sponsor: **OHSU Knight Cancer Institute** · enrollment: 6 (actual)

## Conditions studied

- Advanced Breast Carcinoma
- Advanced Malignant Solid Neoplasm
- Advanced Ovarian Carcinoma
- Advanced Pancreatic Carcinoma
- Advanced Prostate Carcinoma
- Advanced Sarcoma
- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage IV Breast Cancer AJCC v8
- Stage III Ovarian Cancer AJCC v8
- Stage III Pancreatic Cancer AJCC v8
- Stage III Prostate Cancer AJCC v8
- Stage IV Ovarian Cancer AJCC v8
- Stage IV Pancreatic Cancer AJCC v8
- Stage IV Prostate Cancer AJCC v8

## Interventions

- **DRUG:** Abemaciclib
- **PROCEDURE:** Biopsy
- **PROCEDURE:** Bone Scan
- **PROCEDURE:** Echocardiography
- **DRUG:** Exemestane
- **DRUG:** Gemcitabine
- **DRUG:** Letrozole
- **PROCEDURE:** Multigated Acquisition Scan
- **DRUG:** Osimertinib
- **DRUG:** Pemetrexed
- **OTHER:** Survey Administration
- **DRUG:** Tamoxifen
- **PROCEDURE:** Biospecimen Collection

## Key facts

- **NCT ID:** NCT06630325
- **Lead sponsor:** OHSU Knight Cancer Institute
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2025-06-24
- **Primary completion:** 2026-03-11
- **Final completion:** 2026-03-11
- **Target enrollment:** 6 (ACTUAL)
- **Why stopped:** Loss of support.
- **Last updated:** 2026-04-28

## Collaborators

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- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06630325

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06630325, "A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer". Retrieved via AI Analytics 2026-07-25 from https://api.ai-analytics.org/clinical/NCT06630325. Licensed CC0.

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