# A Study of Aticaprant Plus an Antidepressant to Prevent Return of Depression Symptoms in Participants With Major Depressive Disorder Who Experience a Loss of Interest and Pleasure

> **NCT06635135** · PHASE3 · TERMINATED · sponsor: **Janssen Research & Development, LLC** · enrollment: 47 (actual)

## Conditions studied

- Depressive Disorder, Major
- Anhedonia

## Interventions

- **DRUG:** Aticaprant
- **OTHER:** Placebo

## Key facts

- **NCT ID:** NCT06635135
- **Lead sponsor:** Janssen Research & Development, LLC
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2024-09-19
- **Primary completion:** 2025-04-09
- **Final completion:** 2025-04-25
- **Target enrollment:** 47 (ACTUAL)
- **Why stopped:** Early study termination due to insufficient efficacy.
- **Last updated:** 2026-03-12


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06635135

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06635135, "A Study of Aticaprant Plus an Antidepressant to Prevent Return of Depression Symptoms in Participants With Major Depressive Disorder Who Experience a Loss of Interest and Pleasure". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT06635135. Licensed CC0.

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