# EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active

> **NCT06649058** · PHASE2 · RECRUITING · sponsor: **M.D. Anderson Cancer Center** · enrollment: 316 (estimated)

## Conditions studied

- Brain Metastases

## Interventions

- **OTHER:** Systemic Therapy
- **RADIATION:** Stereotactic Radiosurgery

## Key facts

- **NCT ID:** NCT06649058
- **Lead sponsor:** M.D. Anderson Cancer Center
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-02-14
- **Primary completion:** 2028-09-30
- **Final completion:** 2030-09-30
- **Target enrollment:** 316 (ESTIMATED)
- **Last updated:** 2026-04-15


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06649058

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06649058, "EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT06649058. Licensed CC0.

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