# Efficacy and Safety of N-Acetylcysteine Versus Alpha-Lipoic Acid in Colistin-Induced Nephrotoxicity

> **NCT06650384** · PHASE2,PHASE3 · COMPLETED · sponsor: **Ain Shams University** · enrollment: 180 (actual)

## Conditions studied

- Nephrotoxicity

## Interventions

- **DRUG:** Addition of sachets of N-acetyl cysteine 1200 mg twice/day to the maintenance dose of colistin
- **DRUG:** Addition of Alpha-lipoic acid 600mg twice daily to the maintenance dose of colistin

## Key facts

- **NCT ID:** NCT06650384
- **Lead sponsor:** Ain Shams University
- **Sponsor class:** OTHER
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2024-11-01
- **Primary completion:** 2026-01-01
- **Final completion:** 2026-02-01
- **Target enrollment:** 180 (ACTUAL)
- **Last updated:** 2026-02-17


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06650384

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06650384, "Efficacy and Safety of N-Acetylcysteine Versus Alpha-Lipoic Acid in Colistin-Induced Nephrotoxicity". Retrieved via AI Analytics 2026-07-19 from https://api.ai-analytics.org/clinical/NCT06650384. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*