# Optimization of Heart Failure (HF) Medical Therapy After Transcatheter Valve Intervention (TVI) in Patients With Heart Failure With Reduced Ejection Fraction (HFrEF)

> **NCT06667128** · NA · NOT_YET_RECRUITING · sponsor: **IRCCS Ospedale San Raffaele** · enrollment: 160 (estimated)

## Conditions studied

- Heart Failure
- Valvulopathy
- Aortic Stenosis
- Aortic Regurgitation Disease
- Mitral Regurgitation
- Tricuspid Regurgitation
- Brain Natriuretic Peptide
- Mitraclip
- TAVI(Transcatheter Aortic Valve Implantation)

## Interventions

- **OTHER:** Rapid Uptitration of Guideline-Directed Medical Therapy
- **DIAGNOSTIC_TEST:** Elecsys® NT-proBNP - Roche Diagnostics
- **OTHER:** Rapid Up-Titration GDMT Group with Hospital Monitoring

## Key facts

- **NCT ID:** NCT06667128
- **Lead sponsor:** IRCCS Ospedale San Raffaele
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2025-02-01
- **Primary completion:** 2026-02-01
- **Final completion:** 2026-02-01
- **Target enrollment:** 160 (ESTIMATED)
- **Last updated:** 2024-11-04

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06667128

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06667128, "Optimization of Heart Failure (HF) Medical Therapy After Transcatheter Valve Intervention (TVI) in Patients With Heart Failure With Reduced Ejection Fraction (HFrEF)". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT06667128. Licensed CC0.

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