# The Proposed Study Aims to Investigate the Impact of Adjunctive Vitamin D Gel Application on Gingival Crevicular Fluid Levels of Alkaline Phosphatase and Interleukin-8 in Periodontitis Patients Undergoing Phase 1 Periodontal Therapy. By Elucidating the Molecular Mechanisms Underlying the Therapeutic

> **NCT06669026** · PHASE2 · COMPLETED · sponsor: **Mansoura University** · enrollment: 50 (actual)

## Conditions studied

- Periodontal Pocket

## Interventions

- **DIETARY_SUPPLEMENT:** vitamin D loaded Poly lactic-co-glycolic acid nanoparticles gel
- **DIETARY_SUPPLEMENT:** vitamin D3 gel (regular non-nanoparticle form)
- **OTHER:** Poly lactic-co-glycolic acid nanoparticles placebo gel
- **PROCEDURE:** only mechanical debridement

## Key facts

- **NCT ID:** NCT06669026
- **Lead sponsor:** Mansoura University
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2023-09-01
- **Primary completion:** 2024-03-15
- **Final completion:** 2024-09-20
- **Target enrollment:** 50 (ACTUAL)
- **Last updated:** 2024-11-01


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT06669026

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT06669026, "The Proposed Study Aims to Investigate the Impact of Adjunctive Vitamin D Gel Application on Gingival Crevicular Fluid Levels of Alkaline Phosphatase and Interleukin-8 in Periodontitis Patients Undergoing Phase 1 Periodontal Therapy. By Elucidating the Molecular Mechanisms Underlying the Therapeutic". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT06669026. Licensed CC0.

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